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张瑜       

 
办公电话:025-85427635
Office Address:
E-Mail:yuzhang@njfu.edu.cn
 
个人简况

1981年生,中共党员,教授,博士生导师。2007年于厦门大学化学系获理学硕士学位;2012年2月于新加坡南洋理工大学化学与生物化学系获博士学位。2012年3月起加入南京林业大学化学工程学院林产化工系。作为项目负责人先后主持了国家自然科学基金2项、国家重点研发计划子课题,江苏省自然科学基金、江苏省高校自然基金等项目。以第一/通讯作者发表SCI收录论文20余篇,授权国家发明专利10余件。担任J Am Chem Sci,ACS Nano,J Med Chem,J Agric Food Chem, Int J Biol Macro等本领域期刊审稿人。


工作经历

2020.7--至今,南京林业大学,化学工程学院,教授

2012.7–2020.6,南京林业大学,化学工程学院,副教授

个人简况

1981年生,中共党员,教授,博士生导师。2007年于厦门大学化学系获理学硕士学位;2012年2月于新加坡南洋理工大学化学与生物化学系获博士学位。2012年3月起加入南京林业大学化学工程学院林产化工系。作为项目负责人先后主持了国家自然科学基金2项、国家重点研发计划子课题,江苏省自然科学基金、江苏省高校自然基金等项目。以第一/通讯作者发表SCI收录论文20余篇,授权国家发明专利10余件。担任J Am Chem Sci,ACS Nano,J Med Chem,J Agric Food Chem, Int J Biol Macro等本领域期刊审稿人。


研究方向

1. 林源活性物质的生物化学利用

2. 林源次生代谢产物的生物合成

3. 林源抗肿瘤活性物质的靶向递送


学术成果

23. Kun Yang, Yixin Dong, Xun Li, Fei Wang, and Yu Zhang*. Dual-Targeted Delivery of Paclitaxel and Indocyanine Green with Aptamer-Modified Ferritin for Synergetic Chemo-Phototherapy. Colloids and Surface B: Biointerface 2023, 229,113437.

22. Chen Ning, Yixin Dong, Kun Yang, Xun Li, Fei Wang, Yu Zhang*. Co-Encapsulation of Hydrophilic and Hydrophobic Drugs into Human H Chain Ferritin Nanocarrier Enhances Antitumor Efficacy. ACS Biomateri Sci Eng 2023, 2572-2583.

21. Yixin Dong, Kun Yang, Zicheng Xu, Xun Li, Fei Wang,* and Yu Zhang*. Effective Delivery of Paclitaxel-Loaded Ferritin via Inverso CendR Peptide for Enhanced Cancer Therapy. Molecular Pharmaceutics 2023, 20, 942-952.

20. Pingping Qu, Dongdong Li, Raudah Lazim, Rui Xu, Dunchi Xiao, Fei Wang, Xun Li*, Yu Zhang*. Improved thermostability of Thermomyces lanuginosus lipase by molecular dynamics simulation and in silico mutation prediction and its application in biodiesel production. Fuel 2022, 327, 125039.

19. Bingyan Yang, Yixin Dong, Zicheng Xu, Xun Li, Fei Wang, Yu Zhang*. Improved stability and pharmacokinetics of wogonin through loading into PASylated ferritin. Colloids and Surface B: Biointerface 2022, 216, 112515 

18. Jinmiao Sun, Yixin Dong, Xun Li, Fei Wang, Yu Zhang*. Chitosan binding to a novel alfalfa phytoferritin nanocage loaded with baicalein: Simulated digestion and absorption evaluation. Food Chemistry 2022, 386, 132716.

17. Yixin Dong, Yuanmeng Ma, Xun Li, Fei Wang, Yu Zhang*. ERK-Peptide-Inhibitor-Modified Ferritin Enhanced the Therapeutic Effects of Paclitaxel in Cancer Cells and Spheroids. Molecular Pharmacutics 2021, 18, 3365-3377.

16. Yuanmeng Ma, Yixin Dong, Xun Li, Fei Wang, Yu Zhang*. Tumor-Penetrating Peptide-Functionalized Ferritin Enhances Antitumor Activity of Paclitaxel. ACS Applied Bio Materials 2021 4, 3,2654-2663.

15. Yuanmeng Ma, Ruike Li, Yixin Dong, Chaoqun You, Shenlin Huang, Xun Li, Fei Wang, Yu Zhang*. tLyP-1 Peptide Functionalized Human H Chain Ferritin for Targeted Delivery of Paclitaxel. International Journal of Nanomedicine 2021, 16, 789-802.

14. Bingyan Yang, Yixin Dong, Fei Wang and Yu Zhang*. Nanoformulations to enhance the bioavailability and physiological functions of polyphenols. Molecules 2020,25,4613.

13. Ruike Li, Yuanmeng Ma, Yixin Dong, Zhujun Zhao, Chaoqun You, Shenlin Huang, Xun Li, Fei Wang, Yu Zhang*. Novel paclitaxel-loaded nanoparticles based on human H chain ferritin for tumor-targeted delivery. ACS Biomaterials Science & Engineering 2019, 5, 6645-6654.

12. Yu Zhang*, Yixin Dong, Jinhua Zhou, Ying’ao Hu, Xun Li and Fei Wang. Peptide-Mediated Immobilization on Magnetoferritin for Enzyme Recycling. Nanomaterials 2019, 9, 1558.

11. Yu Zhang*, Yixin Dong, Xun Li, and Fei Wang. Proanthocyanidin Encapsulated in Ferritin Enhances Its Cellular Absorption and Antioxidant Activity. Journal of Agricultural and Food Chemistry 2019, 67, 11498-11507.

10. Yu Zhang*, Yixin Dong, Jinhua Zhou, Xun Li, Fei Wang. Application of Plant Viruses as a Biotemplate for Nanomaterial Fabrication. Molecules 2018, 23, 2311.

9. Yu Zhang*, Jinhua Zhou, Maziar S. Ardejani, Xun Li, Fei Wang and Brendan P. Orner. Designability of Aromatic Interaction Networks at E. coli Bacterioferritin B-Type Channels. Molecules 2017, 22(12), 2184.

8. Yu Zhang, Huaxiang Gu, Hao Shi, Fei Wang, and Xun Li*. Green Synthesis of Conjugated Linoleic Acids from Plant Oils Using a Novel Synergistic Catalytic System. Journal of Agriculture and Food Chemistry 2017, 65, 5322−5329.

7. Yu Zhang*, Maziar S. Ardejani, Brendan P. Orner*. Design and Applications of Protein-Cage-Based Nanomaterials. Chemistry-An Asian Journal 2016, 11(20), 2814-2828.

6. Yu Zhang, Lijun Wang, Maziar S. Ardejani, Nur Fazlina Aris, Xun Li, Brendan P. Orner and Fei Wang*, Mutagenesis study to disrupt electrostatic interactions on the twofold symmetry interface of Escherichia coli bacterioferritin (2015). Journal of Biochemistry, 158, 505-512.

5. Yu Zhang*, Maziar S. Ardejani. Differential scanning calorimetry to quantify the stability of protein cages (2015). Methods in Molecular Biology.1252, 101-113.

4. Hao Shi#, Yu Zhang#, Hui Zhong, Yingjuan Huang, Xun Li, Fei Wang*. Cloning, over-expression and characterization of a thermotolerant xylanase from Thermotoga thermarum (2013). Biotechnol Lett, 36, 587-593.

3. Yu Zhang, Brendan P. Orner. Self-assembly in the ferritin nano-cage protein superfamily (2011). Int. J. Mol. Sci. 12, 5406-5421.

2. Yu Zhang, Jing Fu, Sze Y. Chee, Emmiline X. W. Ang, Brendan P. Orner. Rational disruption of the oligomerization of the Mini-Ferritin E. coli DPS through protein-protein interface mutation (2011). Protein Sci. 20, 1907-1917. (Cover paper)

1. Yu Zhang, Siti Raudah Mohamed Lazim, Huihian Teo, Gwenda W. S. Teo, Rongli Fan, Xiaoming Sun, Brendan P. Orner. Alanine-shaving Mutagenesis to Determine Key Interfacial Residues Governing the Assembly of a Nano-cage Maxi-ferritin (2010) J.Bio.Chem. 285, 12078-12086. (Paper of the week, highlighted by ACS Chemical Biology)

 

中文核心:

2. 张瑜*,刘中车,王丽君,李迅,王飞. N端延长对大肠杆菌铁蛋白结构稳定性及其自组装的影响. 南京林业大学学报(自然科学版),2017, 41(1), 35-41.

1. 张瑜*,周金花,周亦琛,李迅,王飞. 血红素对大肠杆菌铁蛋白稳定性及自组装的影响. 生命科学研究,2017,21(4),283-288.


授权专利:

[1] 张瑜,李瑞珂,赵竹君,熊又沣,黄申林,李迅,王飞. 一种以去铁蛋白为载体制备紫杉醇纳米药物并回收紫杉醇的方法. 2022-10-10,中国,ZL201910416536.4

[2] 张瑜,董亦馨,周金花,戚岚岚,李迅,王飞. 一种通过磁性铁蛋白表面展示实现酶固定的方法. 2022-9-21.  中国,ZL201910698944.3

[3] 张瑜,董亦馨,王飞,李迅,杨昆. 一种修饰了D型肿瘤穿透肽的铁蛋白载药纳米粒的制备方法,2022-9-13,中国, ZL202210137407.3

[4] 张瑜,孙金苗, 李迅,王飞,杨冰燕,董亦馨. 一种紫花苜蓿植物铁蛋白的表达纯化方法及其应用,2021-12-7,中国,CN202011462595.4

[5] 张瑜,马原蒙,王飞,李迅,董亦馨. 一种C端修饰肿瘤穿透肽RGERPPR的铁蛋白纳米粒子、其制备方法及应用,2021-9-24,中国,ZL202011413895.3

[6] 张瑜,孙金苗,杨冰燕,董亦馨,李迅,王飞. 一种绿藻植物铁蛋白的表达纯化方法及其应用,2022-11-2,中国, ZL202011151848.6

[7] 张瑜,宁晨,董亦馨,王飞,李迅,杨昆. 一种共载阿霉素和熊果酸的铁蛋白纳米粒的制备方法及应用. 2022-10-28,中国, ZL202210273421.6

[8] 张瑜、渠萍萍、李冬冬、李迅、王飞、许蕊、肖敦驰. 一种疏棉状嗜热丝孢菌脂肪酶突变体G91C及其应用,2022-9-5,中国,ZL202111223379.9

[9] 张瑜,周亦琛,王飞,李迅,徐徐. 一种去除血红素的大肠杆菌铁蛋白突变体及包含它的重组体系. 2019-9-20,中国,CN201511023762.4

[10]  张瑜,杨冰燕,王飞,李迅,董亦馨. 一种负载SN-38的铁蛋白纳米粒及其制备方法和应用. 2023-1-6. 中国,ZL202210677167.6.


课程名称、上课时间地点

本科课程:《植物生物化学(双语)》、《蛋白质化学》

研究生课程:《现代生物技术(全英授)》;《生物能源专题(全英授)》

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